HPE Proliant DL345 Gen10 Plus Server

HPE ProLiant DL345 Gen10 Plus overview

HPE ProLiant DL345 Gen10 Plus is a flexible 2U, single-socket rack server for workloads that need high AMD EPYC core density, large DDR4 memory capacity, PCIe Gen4 expansion and strong local storage flexibility. As an HPE DL345 Gen10 Plus 2U rack server, it is based on AMD EPYC 7003 Series processors, with selected AMD EPYC 7002P options, HPE DDR4 Smart Memory and HPE iLO 5 management.

The HPE ProLiant DL345 Gen10 Plus server is suitable for virtualization, containers, databases, data management, software-defined storage, backup infrastructure, high-performance computing, memory-centric workloads and selected GPU-accelerated workloads. It should be treated as a purpose-built 1P AMD platform, not as a dual-socket Intel replacement. Compared with older Gen10 platforms, DL345 Gen10 Plus brings AMD EPYC 7003 support, DDR4 memory speeds up to 3200 MT/s and PCIe Gen4 I/O.

When to choose HPE ProLiant DL345 Gen10 Plus

Choose HPE ProLiant DL345 Gen10 Plus when the workload needs a 2U single-socket AMD EPYC server with high core count, large memory footprint and flexible local storage. It is a good fit for virtualization hosts, private cloud nodes, containers, analytics, memory-heavy applications, backup repositories and storage-oriented infrastructure where CPU cores, RAM, drive layout and network options must be balanced carefully.

Compared with a 1U AMD server such as HPE ProLiant DL325 Gen10 Plus v2 8SFF, the HPE DL345 Gen10 Plus provides more physical space for front drive bays, rear drive options, airflow and serviceability. Compared with a dual-socket AMD platform such as HPE ProLiant DL365 Gen10 Plus, it is better when one EPYC processor provides enough compute and the project prioritizes cost, storage density and platform simplicity.

The HPE DL345 Gen10 Plus configuration should be validated for processor choice, memory population, chassis type, drive cage layout, storage controller, risers, OCP or stand-up NICs, power supplies, fan kits and cooling. This is especially important for 12LFF, 24SFF, 24NVMe, rear 2SFF, 280W CPU, NVIDIA A10 GPU, 100/200GbE, InfiniBand and tri-mode storage configurations. If the project requires a newer AMD storage platform, compare with HPE ProLiant DL345 Gen11; if it requires Intel-based 2U infrastructure, compare with HPE ProLiant DL380 Gen10 Plus.

Chassis and drive bay options

HPE ProLiant DL345 Gen10 Plus supports several 2U chassis and drive bay layouts. The right option depends on whether the server is configured for virtualization, local capacity, dense SSD storage, NVMe performance, backup or software-defined storage.

For capacity workloads, LFF configurations are usually the practical starting point. For application responsiveness and virtualization datastores, SFF SSD configurations should be considered. For latency-sensitive databases and high-IO workloads, U.3 or U.2 NVMe configurations are more suitable, but NVMe support should not be assumed from the model name alone.

Final drive compatibility depends on chassis, backplane, drive cage, controller, cables, risers, fan kits, power supplies and HPE support matrix.

Recommended HPE ProLiant DL345 Gen10 Plus configurations by workload

The HPE DL345 Gen10 Plus configuration should be chosen around the main reason for selecting this 2U AMD platform: high single-socket core density, DDR4 memory capacity, PCIe Gen4 expansion, flexible SFF/LFF/NVMe storage and proven HPE management.

How to choose CPU, RAM, RAID and storage

HPE ProLiant DL345 Gen10 Plus supports one AMD EPYC processor, including 7003 Series models up to 64 cores and 280W. Higher core counts help virtualization, containers, analytics and multi-user services, while higher-frequency EPYC F-series CPUs can matter for databases and latency-sensitive workloads. 280W processors require maximum performance cooling, and processors at or above 180W require the high-performance heatsink.

RAM planning should start with VM density, database cache, memory-centric workloads and future growth. DL345 Gen10 Plus supports 16 DIMM slots, 8 memory channels and up to 2 DIMMs per channel. Maximum memory is up to 1 TB with 16 × 64 GB RDIMM or up to 4 TB with 16 × 256 GB LRDIMM. Memory speed can reach 3200 MT/s, but it depends on processor, DIMM type and population.

HPE Smart Storage SR100i Gen10 Plus software RAID supports selected SATA or limited U.3 NVMe boot/data layouts in UEFI mode and supports Microsoft Windows Server only. For Linux, VMware, SAS storage, larger arrays, performance RAID or NVMe/SAS/SATA tri-mode designs, use supported Smart Array, MegaRAID or SmartRAID controllers. Performance controllers require the appropriate Smart Storage Battery or Hybrid Capacitor.

For storage, LFF HDDs are capacity-oriented, SFF SSDs are better for application responsiveness, and U.2/U.3 NVMe is best for low-latency workloads when the selected chassis, drive cage, risers, cables and fan kit support it. Boot media can be separated with NS204i-p NVMe, microSD, USB, M.2 SATA or controller-based options where supported.

HPE ProLiant DL345 Gen10 Plus vs related HPE models

HPE ProLiant DL345 Gen10 Plus is the right reference point when the requirement is a 2U single-socket AMD EPYC server with strong local storage flexibility. It is not the same platform as DL385 Gen10 Plus and should not be described as a lower-cost equivalent of a dual-socket AMD server.

New and refurbished HPE ProLiant DL345 Gen10 Plus servers

A refurbished HPE DL345 Gen10 Plus can be a practical production option when it is tested, correctly configured and supplied with warranty. It can reduce acquisition cost for virtualization, containers, databases, backup, software-defined storage, analytics, HPC and mixed infrastructure while keeping the environment on a PCIe Gen4 AMD EPYC platform.

New units may be preferable when procurement policy requires new hardware or when a specific configuration is needed for a standardized rollout. Servermall offers EU delivery and warranty options for HPE ProLiant DL345 Gen10 Plus systems. Before ordering, confirm condition, warranty, lead time, CPU, RAM, drive layout, controller, network cards, risers, power supplies, rail kit and configuration details.

Summary: is HPE ProLiant DL345 Gen10 Plus the right server for your workload×

HPE ProLiant DL345 Gen10 Plus is a flexible 2U AMD EPYC rack server for virtualization, containers, databases, backup, software-defined storage, analytics, HPC, memory-centric workloads and selected GPU workloads. Choose it when you need a single-socket AMD platform with high core count, DDR4 memory, PCIe Gen4, 8SFF, 24SFF, 8LFF, 12LFF, rear 2SFF or NVMe storage options and HPE iLO 5 management. Consider DL325 Gen10 Plus v2 for 1U density, DL385 Gen10 Plus for dual-socket AMD scale, DL345 Gen11 for DDR5 and PCIe Gen5, or DL380 Gen10 Plus for an Intel-based 2U alternative. Before purchase, confirm CPU, RAM, storage, RAID/HBA, network, risers, cooling, PSU, GPU and warranty requirements.