HPE Proliant ML350 Gen12 Server
You might be interested in
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Condition
Refurbished
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CPU
2×8GB DDR4 RDIMM 2133MHz
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RAM
noHDD (up to 8 HDD 2.5'' SFF)
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Condition
Refurbished
-
CPU
2×8GB DDR4 RDIMM 2133MHz
-
RAM
noHDD (up to 8 HDD 2.5'' SFF)
-
Condition
Refurbished
-
CPU
2×8GB DDR4 RDIMM 2133MHz
-
RAM
noHDD (up to 8 HDD 2.5'' SFF)
-
Condition
Refurbished
-
CPU
2×8GB DDR4 RDIMM 2133MHz
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RAM
noHDD (up to 8 HDD 2.5'' SFF)
Processor
1 or 2 Intel® Xeon® 6700/6500 series processors with P-cores, 8 to 86 P-cores per socket, up to 3.5 GHz and up to 336 MB L3 cache
Memory
DDR5 RDIMM: up to 32 x HPE DDR5 Smart Memory DIMMs (8 TB), speeds up to 6400 MT/s depending on processor and population
Storage controllers
- HPE MR216i-o / MR216i-p
- HPE MR408i-o / MR408i-p
- HPE MR416i-o / MR416i-p
- HPE MR932i-p for supported NVMe configurations
Drive bays
Front drive support
- Up to 12 x LFF SAS/SATA drives
- Up to 24 x SFF SAS/SATA/NVMe drives
- Up to 12 x EDSFF NVMe SSD drives
Power supplies
- 800 W Flex Slot Platinum hot-plug
- 1000 W Flex Slot Titanium hot-plug
- 1600 W Flex Slot Platinum hot-plug
- 1600 W Flex Slot -48 VDC hot-plug
- 1800 W-2200 W Flex Slot Titanium hot-plug
Cooling and fans
Default 3 standard non-hot-plug fans; optional fan kits with up to 8 fans for hot-plug and N+1 redundancy
Dimensions
- Height: 462 mm (18.2 inches)
- Width: 174 mm (6.85 inches)
- Depth: 712 mm (28.0 inches)
- Weight: up to 45.13 kg (99.50 lb)
Form factor
4U tower server, rackable with optional tower-to-rack conversion kit
Embedded management
- HPE iLO 7 Standard with Intelligent Provisioning
- HPE OneView Standard
- HPE iLO Advanced, optional
- HPE OneView Advanced, optional
- HPE Compute Ops Management
- Redfish API support
Security
- UEFI Secure Boot and Secure Start
- Immutable Silicon Root of Trust
- Intel® Software Guard Extensions
- Intel® Trust Domain Extensions
- TPM 2.0 support
- HPE iLO 7 quantum-resistant algorithms and CNSA 2.0 firmware signing
- Front bezel key-lock, intrusion cable option, padlock slot and Kensington lock slot
Networking
- No standard network controller
- Choice of OCP or PCIe stand-up networking controllers
- Up to 2 OCP networking adapters supported, depending on configuration
Ports
Front ports
- 1 x USB-C iLO Service Port
- 1 x USB 3.2 Gen1
- 1 x DisplayPort
Internal ports
- 2 x USB 3.2 Gen1
Rear ports
- 1 x dedicated 1 GbE iLO Management Port
- 2 x USB 3.2 Gen1
- 1 x VGA
- 1 x Serial port, optional
PCIe expansion
Up to 10 x PCIe Gen5 slots and 2 x OCP slots
Optical drive
Optional DVD-ROM or DVD-RW optical drive
Operating systems and virtualization
Certified operating systems and virtualization software are listed in HPE Servers Support and Certification Matrices
HPE ProLiant Compute ML350 Gen12 overview
HPE ProLiant Compute ML350 Gen12 is a powerful 4U tower server with rack conversion capability for SMB, ROBO, retail, enterprise and hybrid infrastructure workloads. It is designed for environments that need strong compute performance, large memory capacity, flexible local storage, PCIe Gen5 expansion and serviceability outside a standard rack-first deployment model.
The HPE ML350 Gen12 server is based on Intel Xeon 6700P-series and 6500P-series processors with Performance Cores, with up to two processors and up to 86 P-Cores per socket. It supports HPE DDR5 Smart Memory with up to 32 DIMM slots, HPE iLO 7 management, PCIe Gen5 expansion, OCP 3.0 networking options and multiple front drive cage layouts for LFF, SFF, NVMe and EDSFF storage.
The HPE ProLiant Compute ML350 Gen12 server is suitable for virtualization, business applications, databases, data management, software-defined storage, backup infrastructure, ROBO deployments, on-premises workloads and selected GPU-accelerated workloads. It should be treated as a high-expandability tower platform, not as an entry-level office server. Compared with previous ML350 generations, Gen12 brings a newer Intel Xeon platform, DDR5 memory up to 6400 MT/s, PCIe Gen5 I/O, HPE iLO 7 management and broader storage and accelerator options.
When to choose HPE ProLiant Compute ML350 Gen12
Choose HPE ProLiant Compute ML350 Gen12 when the workload needs a powerful tower server with dual-socket scalability, high memory capacity, flexible storage and room for expansion. It is a good fit for SMB and branch infrastructure, retail chains, local virtualization, private cloud edge nodes, databases, backup repositories, file services, business applications and mixed on-premises workloads where compute, RAM, storage and network options must be balanced carefully.
Compared with smaller tower platforms such as HPE ProLiant ML30 Gen11 or HPE ProLiant ML110 Gen11, the HPE ML350 Gen12 gives much more processor scale, memory capacity, storage flexibility, PCIe expansion and GPU support. Compared with rack servers such as HPE ProLiant DL360 Gen12 or HPE ProLiant DL380 Gen12, ML350 Gen12 should be selected when tower deployment, office or branch placement, internal expansion and optional rack conversion are more important than rack density.
The HPE ML350 Gen12 configuration should be validated carefully for processor generation, CPU quantity, memory population, drive cage layout, storage controller, risers, OCP networking, GPU options, fan kits, heatsinks, power supplies and cooling. This is especially important for high-TDP processors, EDSFF, NVMe x4, 24-drive SFF, 12LFF, internal LTO and multi-GPU configurations. If the server is converted to rack deployment, plan for 5U of rack space rather than treating it as a standard 4U rack server.
Chassis and drive bay options
HPE ProLiant Compute ML350 Gen12 supports a single flexible tower chassis with multiple optional front drive cage layouts. The right option depends on whether the server is being configured for capacity storage, high-density SFF storage, NVMe performance, EDSFF storage, internal tape backup or GPU-heavy workloads.
| Chassis option | Best for | Comment |
|---|---|---|
| HPE ML350 Gen12 4LFF / 8LFF / 12LFF configurations | Capacity-oriented workloads, backup, archive storage, file services and local repositories | Each 4LFF SAS/SATA drive cage supports up to 4 LFF drives. Up to 3 LFF drive cages can be used for 12 LFF drives. Official maximum hot-plug LFF HDD capacity is up to 312 TB with 12 x 26 TB drives. |
| HPE ML350 Gen12 8SFF Tri-Mode configurations | Virtualization, databases, business applications and SSD-oriented builds | Each 8SFF x1 Tri-Mode cage supports SAS, SATA and NVMe x1 options depending on the selected controller and cabling. Up to 3 drive cages can be used for 24 SFF drives. |
| HPE ML350 Gen12 8SFF x4 NVMe configurations | High-performance local NVMe storage and latency-sensitive workloads | The 8SFF x4 NVMe drive cage supports NVMe-focused builds. With x4 cabling, up to 2 cages can support 16 NVMe drives. With x2 cabling, up to 3 cages can support 24 NVMe drives. Final compatibility depends on controller, cabling and processor configuration. |
| HPE ML350 Gen12 12EDSFF NVMe configuration | Dense EDSFF NVMe storage, high-performance databases and analytics | Supports up to one 12EDSFF x4 NVMe drive cage. EDSFF requires careful validation of cabling, controller or direct attach mode, dual-processor requirements, fan kits and inlet temperature rules. |
| HPE ML350 Gen12 internal LTO option | Local tape backup, archive workflows and branch backup infrastructure | Internal LTO tape is supported in selected configurations. When internal LTO is configured, boot options and drive cage count are restricted, and the required cable kit and controller port availability must be checked. |
| HPE ML350 Gen12 NS204i-u V2 boot options | Separating OS or hypervisor boot from front data drives | HPE NS204i-u V2 NVMe Hot Plug Boot Optimized Storage Device is available in 480 GB and 960 GB options, including a 960 GB SED option. It provides RAID1-protected M.2 NVMe boot storage and requires the appropriate front or rear enablement kit. |
For capacity workloads, LFF configurations are usually the practical starting point. For virtualization, databases and mixed enterprise applications, SFF Tri-Mode configurations are often more flexible. For latency-sensitive databases, high-IO virtualization and analytics, NVMe x4 or EDSFF configurations should be considered. NVMe and EDSFF support should not be assumed from the server model name alone; it depends on the exact drive cage, controller, cabling, processor count and HPE-supported option combination.
Final drive compatibility depends on the selected drive cage, storage controller, cable kit, processor count, risers, GPU configuration, cooling configuration and HPE support matrix.
Recommended HPE ProLiant Compute ML350 Gen12 configurations by workload
| Workload | Recommended focus |
|---|---|
| Virtualization / private cloud | Balanced dual-socket CPU configuration, large DDR5 memory pool, SFF SSD or NVMe storage where needed, redundant networking and room for future RAM expansion. |
| SMB / ROBO infrastructure | Single- or dual-socket CPU configuration, protected local storage, iLO management, redundant power and network options sized for the site. |
| Containers / Kubernetes | Balanced CPU and RAM, reliable boot media, fast local SSD or NVMe where needed and redundant network connectivity for cluster traffic. |
| Databases / data management | Processor choice matched to licensing and query profile, enough RAM for cache, low-latency SSD, NVMe or EDSFF storage and protected storage design. |
| Backup / archive | 4LFF, 8LFF or 12LFF capacity layout, HDDs, moderate CPU/RAM, network throughput sized for backup windows and optional internal or external LTO planning. |
| Software-defined storage / HCI | Drive cage layout, HBA/JBOD or controller mode, network bandwidth and CPU/RAM sized for the selected SDS platform. |
| GPU-accelerated workloads | Validated NVIDIA GPU model, x16 riser selection, GPU power cable, External GPU Fan Kit, Redundant Fan Kit, memory sizing and thermal validation. |
| Mixed enterprise workloads | Balanced CPU, RAM, storage and NIC choices, with headroom for failover, maintenance, expansion and cooling. |
The HPE ML350 Gen12 configuration should be chosen around the main reason for selecting a powerful tower server: dual-socket compute, flexible local storage, DDR5 memory capacity, PCIe Gen5 expansion, optional GPU acceleration, HPE iLO 7 management and the ability to deploy outside a rack or convert to rack when needed.
How to choose CPU, RAM, RAID and storage
HPE ProLiant Compute ML350 Gen12 supports up to two Intel Xeon 6700P-series or 6500P-series processors with Performance Cores. Processor options include up to 86 P-Cores per socket and up to 350W TDP. Higher core counts help virtualization, containers, analytics and multi-user services, while higher clock speed can matter for databases and applications sensitive to per-core performance. Processor models cannot be mixed, and high-TDP processors require the correct heatsink and fan kits.
RAM planning should start with VM density, database cache requirements, application growth and future expansion. HPE ML350 Gen12 supports HPE DDR5 Smart Memory RDIMMs with up to 32 DIMM slots, 16 slots per processor, and up to 8 TB maximum memory capacity with 32 x 256 GB RDIMMs. Maximum memory speed depends on processor model and DIMM population; DDR5-6400 DIMMs can run up to 6400 MT/s at 1DPC and up to 5200 MT/s at 2DPC in supported configurations.
Storage planning should begin with the drive cage layout. LFF cages are capacity-oriented and suitable for backup, archive and file services. SFF Tri-Mode cages are better for mixed SAS, SATA and NVMe serviceability. NVMe x4 and EDSFF cages are intended for performance-focused storage. HPE lists maximum storage of up to 312 TB with 12 LFF HDDs, up to 368.64 TB with 24 SFF SAS or NVMe SSDs, and up to 183.6 TB with 12 EDSFF NVMe SSDs.
Hardware RAID is appropriate for classic protected local arrays. HPE MR Gen11 Tri-Mode controllers should be selected according to drive type, drive count, cache requirement and whether the controller is OCP or PCIe. Intel VROC NVMe for HPE ProLiant Gen12 can be used for CPU-attached NVMe SSDs, but RAID support requires the appropriate Intel VROC RAID 1 or Premium licence and operates in UEFI mode only.
GPU, networking and power should be validated as part of the same configuration, not as separate choices. ML350 Gen12 supports selected NVIDIA L4, L40, L40S, RTX A1000 and RTX PRO 4500 accelerators, but GPU use can require x16 risers, GPU power cables, Redundant Fan Kit, Second CPU Fan Kit and External GPU Fan Kit. Networking is selected through OCP or PCIe adapters, and power supply choice should be checked with HPE Power Advisor, especially for GPU, EDSFF, 24-drive, dual-processor or high-TDP builds.
HPE ProLiant Compute ML350 Gen12 vs related HPE models
| Model | When to consider |
|---|---|
| HPE ProLiant ML30 Gen11 | Choose ML30 Gen11 when a lower-cost tower server is enough for small office, light application or basic infrastructure workloads. |
| HPE ProLiant ML110 Gen11 | Choose ML110 Gen11 when a single-socket tower server is preferred and the workload does not need ML350 Gen12 dual-socket scale or storage expansion. |
| HPE ProLiant ML350 Gen11 | Consider ML350 Gen11 when a previous-generation tower platform is sufficient and acquisition cost is the main priority. |
| HPE ProLiant DL320 Gen12 | Choose DL320 Gen12 when a compact single-socket rack server is preferred instead of a tower platform. |
| HPE ProLiant DL360 Gen12 | Choose DL360 Gen12 when 1U rack density is more important than tower serviceability, local expansion or internal storage flexibility. |
| HPE ProLiant DL380 Gen12 | Choose DL380 Gen12 when the workload needs a standard 2U rack platform with dual-socket compute, broad storage layouts and data center rack density. |
HPE ProLiant Compute ML350 Gen12 is the right reference point when the requirement is a high-expandability Intel-based HPE Gen12 tower server with optional rack conversion. It is not the same type of platform as a compact 1U or 2U rack server and should not be positioned only as a tower version of DL380 Gen12.
Summary: is HPE ProLiant Compute ML350 Gen12 the right server for your workload×
HPE ProLiant Compute ML350 Gen12 is a powerful tower server for SMB, ROBO, retail, enterprise, virtualization, databases, backup, software-defined storage, GPU-accelerated workloads and mixed on-premises infrastructure. Choose it when you need an Intel Xeon 6700P/6500P-based HPE Gen12 platform with DDR5 memory, PCIe Gen5 expansion, flexible LFF, SFF, NVMe and EDSFF storage layouts, HPE iLO 7 management and strong expansion in a tower form factor.
Consider ML30 Gen11 or ML110 Gen11 for simpler tower workloads, ML350 Gen11 when a previous-generation tower platform is enough, DL360 Gen12 for 1U rack density or DL380 Gen12 for standard 2U rack infrastructure. Before purchase, confirm processor model, CPU count, RAM population, drive cage layout, RAID/VROC mode, NS204i-u boot option, OCP networking, risers, GPU support, fan kits, heatsinks, power supplies, rack conversion and warranty requirements.
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The Servermall warranty includes:
- Access on a 24x7 basis (including holidays) to the Servermall Customer Service and Support organization for troubleshooting assistance of Servermall Refurbished Servers and Associated Goods and select software issues.
- 5 year warranty. In case of problem diagnostics or repair, we will do on the server installation site. For free.
- On-site dispatch of replacement parts to the Installation Site or other mutually agreed upon Customer’s business location approved by Servermall to address a Product problem.
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